The role of Serotonin in dog anxiety

15th March 2012
Beryl Shuttleworth
12 Responses

When your brain wants to send a message from one neuron to the next, it uses chemical substances called neurotransmitters. One of the major neurotransmitters in the brain is called serotonin. Studies in animals and humans have revealed that serotonin is responsible for feelings of well being, calmness, relaxation, confidence and concentration.

So, what happens if you don’t have enough serotonin? Fear, aggression, anxiety. But you’d be surprised at how often serotonin deficiency is simply due to dietary imbalances. Easy to fix.

This is how serotonin is made in the body:
Tryptophan (an amino acid) is converted into 5-HTP (another amino acid) which in turn, is converted into serotonin (a neurotransmitter).

When we first started making herbal products, we formulated our Calm mix using tryptophan. But we encountered a problem – the product seemed to become less effective with time.

A bit of research showed us where we were going wrong:

  • Tryptophan doesn’t pass easily from the blood into the brain
  • It is also used to make proteins – hence some of it is used elsewhere
  • The liver breaks it down to a mildly toxic substance
  • It feeds back on itself, and inhibits its own conversion to serotonin

Because of these problems, we switched to using 5-HTP. 5-Hydroxy Tryptophan (5-HTP) is also a completely natural substance, derived from the seed pods of Griffonia, a West African plant. Side effects are very rare and 5-HTP has been shown to be VERY effective. (In fact, so effective that is has the manufacturers of Prozac etc. very worried.)

What does this mean in terms of our animals? It means that if you have an overly aggressive, nervous, anxious, timid or overly excitable dog, supplementation with Serenity Formula might just help. Also, with Guy Fawkes coming up, it may make traumatic experiences slightly less traumatic.

More about this article
The role of seratonin in dog anxiety
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The role of seratonin in dog anxiety
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The Herbal Horse and Pet

12 Responses

  1. Hi, just discovered your page while looking for something for my dog. He is 8 years old and always chased his tail, barking but as he is getting older, it is now constant, to where i have to tie him up to stop. I have tried Paws complete calm and it did work a little but now has wornoff. Do you have something to help stop him or at least slow him down a little ? Thanks Sue

    1. Hi Sue. Apologies for the late reply. Please try our Serenity Formula. It sounds like this is nervous behaviour that has become a habit. He might need some training as well….. Best of luck!

  2. My Dog is a Rough Collie, he is 8 months okd and he barks a lot. I work all day and my neighbors are complaining.

  3. My dog has fear aggression and does improve with low protein, natural food. But he is still anxious around lone men and I am looking for a supplement to alleviate this.


    1. Geraldine, it sounds as if you are treating him well. I would suggest trying Serenity Formula as well, it acts like an antidepressant and just makes life a little easier for the dog.

  4. My 1yr old Basset Hound (Droopie) is suffering from epilepsy. Would a product like above help for her sickness?


    1. Nadia, Serenity Formula isn’t specifically for epilepsy. Also I would ask a vet before giving it to your dog – I’m not too sure of the possible interactions with other drugs.

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